Headquartered in Melbourne, Australia, with operations in San Francisco, USA, Alterity Therapeutics is at the forefront of neurodegenerative disease research. The company's lead asset, ATH434, is designed to inhibit the aggregation of pathological proteins implicated in neurodegeneration. ATH434 is currently being evaluated in two Phase 2 clinical trials for Multiple System Atrophy (MSA), a Parkinsonian disorder with no approved disease-modifying treatments.
In January 2025, Alterity announced positive results from the ATH434 Phase 2 trial, demonstrating a clinically meaningful benefit and a favorable safety profile. The trial achieved statistical significance, showing up to a 48% slowing of clinical progression on the Unified Multiple System Atrophy Rating Scale (UMSARS). Additionally, key MRI biomarkers indicated stabilization of iron levels in brain regions affected by MSA.