Established in 2014, Paradigm Biopharmaceuticals aims to transform underutilised molecules into effective treatments for diseases with significant unmet medical needs. The company's lead candidate, Zilosul®, is an injectable PPS drug under development for conditions such as osteoarthritis, mucopolysaccharidosis, and other inflammatory diseases. Paradigm leverages existing molecules, reducing development time and costs, thereby accelerating the delivery of new therapies to patients.
Their immediate commercial focus is the development of injectable pentosan polysulfate sodium (iPPS/PPS), branded as Zilosul®, for the treatment of osteoarthritis (OA). This condition represents a global unmet medical need, and Paradigm has progressed to phase 3 clinical trials. PPS targets all aspects of the disease—reducing inflammation, alleviating pain, and supporting regeneration—with potential as a disease-modifying therapy.