Paradigm Biopharmaceuticals Limited (ASX:PAR)

To develop pharmaceutical therapies that enhance health and quality of life.

About Us

Paradigm Biopharmaceuticals Ltd. is a late-stage drug development company working with world leaders in pharmaceutical product development to approach science from a completely different angle.

Company Overview

Established in 2014, Paradigm Biopharmaceuticals aims to transform underutilised molecules into effective treatments for diseases with significant unmet medical needs. The company's lead candidate, Zilosul®, is an injectable PPS drug under development for conditions such as osteoarthritis, mucopolysaccharidosis, and other inflammatory diseases. Paradigm leverages existing molecules, reducing development time and costs, thereby accelerating the delivery of new therapies to patients.

Their immediate commercial focus is the development of injectable pentosan polysulfate sodium (iPPS/PPS), branded as Zilosul®, for the treatment of osteoarthritis (OA). This condition represents a global unmet medical need, and Paradigm has progressed to phase 3 clinical trials. PPS targets all aspects of the disease—reducing inflammation, alleviating pain, and supporting regeneration—with potential as a disease-modifying therapy.

Board Members

Board & Management

Paul Rennie

Paul Rennie

Founder & Chairman

Mr Rennie is recognised as a leading authority in drug development and has been involved in a number of pre-clinical and clinical trial programs over his accomplished career. He was the inaugural COO of Mesoblast and most recently as Executive VP, New Product Development at Mesoblast Ltd. Mr. Rennie has extensive experience in commercialising Intellectual Property.

Dr Donna Skerrett

Dr Donna Skerrett

Executive Director

Dr. Skerrett, has more than 30 years’ experience in transfusion medicine, cellular therapy, and regenerative medicine. She was the CMO of Mesoblast, a stem cell development company (2011-2019), Dir. Transfusion Medicine & Cellular Therapy at Weill Cornell Medical Center, NY (2004-2011), and Ass. Dir. Transfusion Medicine at Columbia University’s NY-Presbyterian Hospital. She has chaired the NY State Governor’s Council on Blood and Transfusion Service and served on the Board of Directors of the Fox Chase Cancer Center. She currently serves in an advisory role on the Board of Visitors for the Lewis Katz School of Medicine of Temple University.

Amos Meltzer

Amos Meltzer

Non-Executive Director

Amos Meltzer is a scientist and an intellectual property lawyer with over 25 years of experience in international trade and in commercialising technologies principally in the life sciences sector. He has presided over life science research and product development projects clinical trials as well as the commercialisation of life sciences assets through both licensing and the sale and marketing of a pharmaceutical product. Previously Amos has served as in house counsel and IP director at two Nasdaq-listed companies Cgen and Gilat, as a non-executive director of a biotechnology company Evogene and as VP of Business Development and then CEO of an ASX-listed biopharmaceutical company Immuron. Amos currently serves as Chief Operating Officer of neuro- medical device company Synchron, chairman of the board of surgeons’ education services company Vasculab and as a legal advisor to a number of ASX listed and private life science companies.

Matthew Fry

Matthew Fry

Non-Executive Director

Matthew joins the Paradigm board with more than 25 years in business creation, strategy, and expansion in healthcare and medical diagnostics globally. He is currently the CEO, Managing Director and Founder of AM Diagnostics Pty Ltd, a manufacturer and distributor of world class medical diagnostic products.

Matthew has significant experience with global regulatory agencies, in particular the Australian TGA and US FDA. Through his role as Founder and CEO of AM Diagnostics, Matthew drove the company’s expansion into the United States in 2009 and is a leading biotechnology device supplier with a deep understanding of sales channels in both the US medical wholesale market and retail market, and how to negotiate with private health providers.

Paradigm Biopharmaceuticals Limited

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