Alterity Therapeutics Limited (ASX:ATH)

An alternative future.

About Us

Alterity Therapeutics is a clinical-stage biotechnology company dedicated to creating an alternate future for individuals living with neurodegenerative diseases. The company's lead drug candidate, ATH434, has demonstrated efficacy in several animal models of Parkinsonian disorders and is currently being evaluated in clinical trials.

Company Overview

Headquartered in Melbourne, Australia, with operations in San Francisco, USA, Alterity Therapeutics is at the forefront of neurodegenerative disease research. The company's lead asset, ATH434, is designed to inhibit the aggregation of pathological proteins implicated in neurodegeneration. ATH434 is currently being evaluated in two Phase 2 clinical trials for Multiple System Atrophy (MSA), a Parkinsonian disorder with no approved disease-modifying treatments.

In January 2025, Alterity announced positive results from the ATH434 Phase 2 trial, demonstrating a clinically meaningful benefit and a favorable safety profile. The trial achieved statistical significance, showing up to a 48% slowing of clinical progression on the Unified Multiple System Atrophy Rating Scale (UMSARS). Additionally, key MRI biomarkers indicated stabilization of iron levels in brain regions affected by MSA.

Board Members

Lawrence Gozlan

Lawrence Gozlan

Non-Executive Director

Mr Gozlan was appointed as a director of our company on August 8, 2011. Mr. Gozlan, a leading biotechnology investor and advisor, is the Chief Investment Officer and Founder of Scientia Capital, a specialised global investment fund focused exclusively in life sciences. The Company was founded to provide high level expertise and to manage investments for high net worth individuals, family offices and institutional investors wanting exposure to the biotechnology industry.

Prior to this, Mr Gozlan was responsible for the largest biotechnology investment portfolio in Australia as the institutional biotechnology analyst at QIC (“the Queensland Investment Corporation”), an investment fund with over AU$60 billion under management. He previously worked as the senior biotechnology analyst in the equities team at Foster Stockbroking, and gained senior corporate finance experience advising life science companies at Deloitte.

Mr. Gozlan is currently a Director of Opthea Limited, an ASX listed drug development company and AusBiotech, which is the Australian Biotechnology Industry body and a number of private biotechnology companies in the USA.  He holds a Bachelor of Science with Honors in microbiology and immunology from the University of Melbourne specializing in neurodegenerative diseases.

Peter Marks

Peter Marks

Non-Executive Director

Mr Marks has served as a director of Alterity since July 2005.  He is an experienced company director with significant corporate advisory and investment experience. In his roles with these various financial institutions, Mr. Marks was responsible for advising a substantial number of listed and unlisted companies on issues ranging from corporate and company structure, to valuation, business strategies, acquisitions and international opportunities.

For over 13 years until the end of August 2014, Mr. Marks was a Director of investment bank Peregrine Corporate Ltd, and is currently Chairman of Newburyport Partners, a boutique corporate and capital markets advisory firm specializing in advising small to mid-cap companies.

Mr Marks is currently a non-executive Director of  Electriq Global Ltd, and also currently serves as Director of Noxopharm Ltd, an ASX listed biotechnology company, and Noxopharm subsidiary, Nyrada Inc.

David Stamler

David Stamler

Chief Executive Officer

David Stamler, M.D. was appointed Chief Executive Officer in January 2021 and previously served as our Chief Medical Officer and Senior Vice President, Clinical Development since May of 2017.  Prior to joining Alterity, Dr. Stamler served as the Vice President, Clinical Development and Therapeutic Head for Movement Disorders at Teva Pharmaceutical Industries from 2015 to 2017 after Teva acquired Auspex Pharmaceuticals. 

Dr Stamler was the Chief Medical Officer of Auspex from January 2011 until 2015. Prior to that, he served as Senior Vice President and Chief Medical Officer at XenoPort, Inc., a publicly-traded biopharmaceutical company, from 2008 to 2010 and Chief Scientific Officer and Head of Drug Development at Prestwick Pharmaceuticals, Inc., a private pharmaceutical company, from 2005 to 2008. Before Prestwick Pharmaceuticals, Inc., Dr. Stamler worked at Fujisawa Pharmaceutical Co. and its subsidiaries from 1997 to 2005 in various leadership roles, including Vice President, Research and Development, Medical Sciences at Fujisawa Healthcare, Inc. from 2003 to 2005 and as Vice President, Clinical Research Center at Fujisawa Research Institute of America from 2000 to 2003. Dr. Stamler began his career at Abbott Laboratories, a publicly-traded global pharmaceuticals and healthcare products company, where he served in various positions from 1993 to 1997, including Director of Clinical Research, Pharmaceutical Products for the International Division. Dr. Stamler received an M.D. from the University of Chicago—The Pritzker School of Medicine and a B.A. in Biology from the University of Chicago.

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